Answer: The drive from South Carolina to Tallahassee, Florida, is generally straightforward and mostly along well-maintained interstate highways. Depending on your starting point in South Carolina, the most common route is via I-95 south to I-10 west, which takes you directly into Tallahassee. The roads are mostly in good condition, with some areas of construction or maintenance, particularly near urban centers or highway interchanges.

Answer: If you are traveling from the Florida Panhandle toward Orlando and are looking for a one-night stop halfway, both Tallahassee and Lake City are options, but they offer different experiences and considerations regarding safety, convenience, and amenities.